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KMID : 0811720100140050337
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Korean Journal of Physiology & Pharmacology
2010 Volume.14 No. 5 p.337 ~ p.343
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Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex
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Jang Hyun-Jong
Cho Kwang-Hyun
Park Sung-Won
Kim Myung-Jun
Yoon Shin-Hee
Rhie Duck-Joo
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Abstract
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Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. In a previous study, we suggested that a developmental increase in serotonin [5-hydroxytryptamine (5-HT)] might be involved in the decline of LTP, since 5-HT inhibited its induction. In the present study, to further understand the role of 5-HT in a developmental decrease in plasticity, we investigated the effect of 5-HT on the induction of LTD in the pathway from layer 4 to layer 2/3. LTD was inhibited by 5-HT (10?M) in 5-week-old rats. The inhibitory effect was mediated by activation of 5-HT2 receptors. Since 5-HT also regulates the development of visual cortical circuits, we also investigated the role of 5-HT on the development of inhibition. The development of inhibition was retarded by chronic (2 weeks) depletion of endogenous 5-HT in 5-week-old rats, in which LTD was reinstated. These results suggest that 5-HT regulates the induction of LTD directly via activation of 5-HT2 receptors and indirectly by regulating cortical development. Thus, the present study provides significant insight into the roles of 5-HT on the development of visual cortical circuits and on the age-dependent decline of long-term synaptic plasticity.
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KEYWORD
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5-HT, Development, GABA, Inhibition, LTD, Synaptic plasticity, Visual cortex
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